Side Effects

Sermorelin has a well-established safety profile from its years as an FDA-approved medication. The following come from clinical trials and post-marketing experience.

Common (usually mild, self-limiting)

  • Facial flushing - brief warmth/redness, usually resolving within 5-20 minutes
  • Mild headache, most often in the first 1-2 weeks

Less common

  • Nausea; drowsiness or restlessness
  • Transient urticaria (hives); mild water retention
  • Difficulty swallowing (rare); altered taste

Rare but significant

  • Hypersensitivity reactions (facial swelling, breathing difficulty, anaphylaxis) - require immediate medical attention
  • Anti-sermorelin antibody formation (common at least once in pediatric trials, often transient, generally without effect on growth outcomes)